Volume 9, Issue 11 p. 1701-1705
Communication

Peptide Tertiary Structure Nucleation by Side-Chain Crosslinking with Metal Complexation and Double “Click” Cycloaddition

Oscar Torres

Oscar Torres

Department of Chemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA), Fax: (+1) 614-292-1685

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Deniz Yüksel

Deniz Yüksel

Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155 (USA)

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Matt Bernardina

Matt Bernardina

Department of Chemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA), Fax: (+1) 614-292-1685

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Krishna Kumar Prof.

Krishna Kumar Prof.

Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, MA 02155 (USA)

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Dennis Bong Prof.

Dennis Bong Prof.

Department of Chemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, OH 43210 (USA), Fax: (+1) 614-292-1685

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First published: 11 July 2008
Citations: 26

Graphical Abstract

Dimerization assist: Folding-incompetent peptides are restored to dimerization capability by side-chain crosslinking using both Ni2+–histidine complexation and a novel double “click” cycloaddition between the i and i+4 azidoalanine residues and synthetic bisalkyne linkers.