Volume 17, Issue 13 p. 1191-1197
Concept

Emerging Diversity of the Cobalamin-Dependent Methyltransferases Involving Radical-Based Mechanisms

Prof. Dr. Wei Ding

Prof. Dr. Wei Ding

Key Laboratory of Cell Activities and Stress Adaptations, (Ministry of Education), School of Life Sciences, Lanzhou University, Lanzhou, 730000 China

Department of Chemistry, Fudan University, Shanghai, 200433 China

These authors contributed equally to this work.

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Qien Li

Qien Li

Key Laboratory of Cell Activities and Stress Adaptations, (Ministry of Education), School of Life Sciences, Lanzhou University, Lanzhou, 730000 China

These authors contributed equally to this work.

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Youli Jia

Youli Jia

Key Laboratory of Cell Activities and Stress Adaptations, (Ministry of Education), School of Life Sciences, Lanzhou University, Lanzhou, 730000 China

Department of Chemistry, Fudan University, Shanghai, 200433 China

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Xinjian Ji

Xinjian Ji

Department of Chemistry, Fudan University, Shanghai, 200433 China

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Haocheng Qianzhu

Haocheng Qianzhu

Department of Chemistry, Fudan University, Shanghai, 200433 China

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Prof. Dr. Qi Zhang

Corresponding Author

Prof. Dr. Qi Zhang

Department of Chemistry, Fudan University, Shanghai, 200433 China

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First published: 30 March 2016
Citations: 27

Graphical Abstract

A radical approach: Although many cobalamin-dependent methyltransferases have been extensively investigated, a new group of these compounds that utilizes radical chemistry is just beginning to be appreciated. The functional and mechanistic diversity of this emerging class of enzymes is discussed in detail in this Concept article.

Abstract

Cobalamins comprise a group of cobalt-containing organometallic cofactors that play important roles in cellular metabolism. Although many cobalamin-dependent methyltransferases (e.g., methionine synthase MetH) have been extensively studied, a new group of methyltransferases that are cobalamin-dependent and utilize radical chemistry in catalysis is just beginning to be appreciated. In this Concept article, we summarize recent advances in the understanding of the radical-based and cobalamin-dependent methyltransferases and discuss the functional and mechanistic diversity of this emerging class of enzymes.