In Situ Generation and Intramolecular Schmidt Reaction of Keto Azides in a Microwave-Assisted Flow Format
Dr. Thomas O. Painter
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Search for more papers by this authorDr. Paul D. Thornton
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Search for more papers by this authorMario Orestano
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Department of Chemistry, York University, 4700 Keele St., Ontario (Canada)
Search for more papers by this authorDr. Conrad Santini
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Search for more papers by this authorProf. Michael G. Organ
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Department of Chemistry, York University, 4700 Keele St., Ontario (Canada)
Search for more papers by this authorCorresponding Author
Prof. Jeffrey Aubé
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Department of Medicinal Chemistry, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA)
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179Search for more papers by this authorDr. Thomas O. Painter
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Search for more papers by this authorDr. Paul D. Thornton
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Search for more papers by this authorMario Orestano
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Department of Chemistry, York University, 4700 Keele St., Ontario (Canada)
Search for more papers by this authorDr. Conrad Santini
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Search for more papers by this authorProf. Michael G. Organ
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Department of Chemistry, York University, 4700 Keele St., Ontario (Canada)
Search for more papers by this authorCorresponding Author
Prof. Jeffrey Aubé
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179
Department of Medicinal Chemistry, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA)
Chemical Methodology and Library Development Center, University of Kansas, Delbert M. Shankel Structural Biology Center, 2034 Becker Drive, Lawrence, KS 66047-3761 (USA), Fax: (+1) 785-864-8179Search for more papers by this authorGraphical Abstract
Go with the flow! A method for conversion of keto halides to lactams by means of sequential azidation and intramolecular Schmidt reaction in a combined flow format is described (see scheme; MWI=microwave irradiation, TFA=trifluoroacetic acid).
Supporting Information
Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors.
| Filename | Description |
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| chem_201100768_sm_miscellaneous_information.pdf2.8 MB | miscellaneous_information |
Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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