Review
Direct α-Functionalization of Saturated Cyclic Amines
Dr. Emily A. Mitchell,
Dr. Aldo Peschiulli,
Dr. Nicolas Lefevre,
Dr. Lieven Meerpoel,
Prof. Dr. Bert U. W. Maes,
Dr. Emily A. Mitchell
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233
Search for more papers by this authorDr. Aldo Peschiulli
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233
Search for more papers by this authorDr. Nicolas Lefevre
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233
Search for more papers by this authorDr. Lieven Meerpoel
Janssen Research & Development, Janssen Pharmaceutica N.V. Turnhoutseweg 30, 2340 Beerse (Belgium)
Search for more papers by this authorCorresponding Author
Prof. Dr. Bert U. W. Maes
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233Search for more papers by this authorDr. Emily A. Mitchell,
Dr. Aldo Peschiulli,
Dr. Nicolas Lefevre,
Dr. Lieven Meerpoel,
Prof. Dr. Bert U. W. Maes,
Dr. Emily A. Mitchell
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233
Search for more papers by this authorDr. Aldo Peschiulli
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233
Search for more papers by this authorDr. Nicolas Lefevre
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233
Search for more papers by this authorDr. Lieven Meerpoel
Janssen Research & Development, Janssen Pharmaceutica N.V. Turnhoutseweg 30, 2340 Beerse (Belgium)
Search for more papers by this authorCorresponding Author
Prof. Dr. Bert U. W. Maes
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233
Organic Synthesis, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp (Belgium), Fax: (+32) 32653233Search for more papers by this authorGraphical Abstract
On the bumpy road to direct success: With a growing number of convenient synthetic methodologies at hand, the direct α-functionalization of cyclic amines has become more straightforward than ever before. This Review covers the recent methodological advances in this challenging field (from the end of 2006) and classifies them according to their associated in situ formed reactive intermediates.
Abstract
Recent advances in synthetic methods for the direct α-functionalization of saturated cyclic amines are described. Methods are categorized according to the in situ formed reactive intermediate (α-amino cation, α-amino anion, and α-amino radical). Transition-metal-catalyzed reactions involving other intermediates have been treated as a separate and fourth class.
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Citing Literature
Special Issue:Conference Issue: 4th European Chemistry Congress, Prague
August 13, 2012
Pages 10092-10142
