Minireview
Application of In Situ Product Crystallization and Related Techniques in Biocatalytic Processes
Dennis Hülsewede,
Lars-Erik Meyer,
Dr. Jan von Langermann,
Dennis Hülsewede
Biocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, A-Einstein-Str. 3A, 18059 Rostock, Germany
These authors contributed equally to this work.
Search for more papers by this authorLars-Erik Meyer
Biocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, A-Einstein-Str. 3A, 18059 Rostock, Germany
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Dr. Jan von Langermann
Biocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, A-Einstein-Str. 3A, 18059 Rostock, Germany
Search for more papers by this authorDennis Hülsewede,
Lars-Erik Meyer,
Dr. Jan von Langermann,
Dennis Hülsewede
Biocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, A-Einstein-Str. 3A, 18059 Rostock, Germany
These authors contributed equally to this work.
Search for more papers by this authorLars-Erik Meyer
Biocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, A-Einstein-Str. 3A, 18059 Rostock, Germany
These authors contributed equally to this work.
Search for more papers by this authorCorresponding Author
Dr. Jan von Langermann
Biocatalytic Synthesis Group, Institute of Chemistry, University of Rostock, A-Einstein-Str. 3A, 18059 Rostock, Germany
Search for more papers by this authorGraphical Abstract
Crystallization and biocatalysis: In situ product crystallization is a powerful technique to overcome fundamental limitations in biocatalytic reactions, for example, unfavorable reaction equilibria or product inhibitions (see figure). This Minireview presents basic process considerations within (early) process development and illustrates the high potential of crystallization with selected examples.
Abstract
This Minireview highlights the application of crystallization as a very powerful in situ product removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its use for in situ product crystallization (ISPC) to overcome unfavorable thermodynamic reaction equilibria, inhibition, and undesired reactions. The combination of these unit operations requires an interdisciplinary perspective to find a holistic solution for the underlying bioprocess intensification approach. Representative examples of successful integrated process options are selected, presented, and assessed regarding their overall productivity and applicability. In addition, parallels to the use of adsorption as a very similar technique are drawn and similarities discussed.
Conflict of interest
The authors declare no conflict of interest.
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