Volume 27, Issue 4 p. 1231-1257
Review

Chiral Catalysts for Pd0-Catalyzed Enantioselective C−H Activation

Oleksandr Vyhivskyi

Oleksandr Vyhivskyi

Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland

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Anton Kudashev

Anton Kudashev

Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland

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Takeru Miyakoshi

Takeru Miyakoshi

Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland

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Prof. Dr. Olivier Baudoin

Corresponding Author

Prof. Dr. Olivier Baudoin

Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland

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First published: 07 August 2020
Citations: 70

Graphical Abstract

Enantioselective C−H activation is a powerful tool to build scalemic chiral molecules from simple precursors. This review covers Pd0-catalyzed enantioselective C−H activation reactions, which usually employ chiral catalysts evolved from cross-couplings and allow generation of different types of stereogenic elements with a high degree of stereocontrol.

Abstract

In the past few decades, processes that involve transition-metal catalysis have represented a major part of the synthetic chemist′s toolbox. Recently, the interest has shifted from the well-established cross-coupling reactions to C−H bond functionalization, thus making it a current frontier of transition-metal-catalyzed reactions. Constant progress in this field has led to the discovery of enantioselective methods to generate and control various types of stereogenic elements, thereby demonstrating its high value to generate scalemic chiral molecules. The present review is dedicated to enantioselective Pd0-catalyzed C−H activation, which may be considered as an evolution of Pd0-catalyzed cross-couplings, with a focus on the different chiral ligands and catalysts that enable these transformations.

Conflict of interest

The authors declare no conflict of interest.