Review
Exploring the Potential of Metallodrugs as Chemotherapeutics for Triple Negative Breast Cancer
Nazia Nayeem,
Prof. Maria Contel,
Nazia Nayeem
Brooklyn College Cancer Center BCCC-CURE, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210 USA
Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210 USA
Biology PhD Program, The Graduate Center, The City University of New York, 365 5th Avenue, New York, New York, 11006 USA
Search for more papers by this authorCorresponding Author
Prof. Maria Contel
Brooklyn College Cancer Center BCCC-CURE, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210 USA
Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210 USA
Biology PhD Program, The Graduate Center, The City University of New York, 365 5th Avenue, New York, New York, 11006 USA
Chemistry and Biochemistry PhD Programs, The Graduate Center, The City University of New York, 365 5th Avenue, New York, New York, 11006 USA
University of Hawaii Cancer Center, 701 Ilalo St, Honolulu, Hawaii, 96813 USA
Search for more papers by this authorNazia Nayeem,
Prof. Maria Contel,
Nazia Nayeem
Brooklyn College Cancer Center BCCC-CURE, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210 USA
Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210 USA
Biology PhD Program, The Graduate Center, The City University of New York, 365 5th Avenue, New York, New York, 11006 USA
Search for more papers by this authorCorresponding Author
Prof. Maria Contel
Brooklyn College Cancer Center BCCC-CURE, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210 USA
Department of Chemistry, Brooklyn College, The City University of New York, 2900 Bedford Avenue, Brooklyn, New York, 11210 USA
Biology PhD Program, The Graduate Center, The City University of New York, 365 5th Avenue, New York, New York, 11006 USA
Chemistry and Biochemistry PhD Programs, The Graduate Center, The City University of New York, 365 5th Avenue, New York, New York, 11006 USA
University of Hawaii Cancer Center, 701 Ilalo St, Honolulu, Hawaii, 96813 USA
Search for more papers by this authorDedicated to all scientists affected by breast cancer.
Graphical Abstract
Triple negative breast cancer (TNBC) has one of the poorest prognoses and worst survival rates for patients, with chemotherapy still the gold standard for treatment. This review collects information on all metallodrugs studied in TNBC cells and tumors, focusing on mechanistic and in vivo studies. An outlook towards TNBC metallodrugs with translational potential is provided.
Abstract
This review focuses on studies of coordination and organometallic compounds as potential chemotherapeutics against triple negative breast cancer (TNBC) which has one of the poorest prognoses and worst survival rates from all breast cancer types. At present, chemotherapy is still the standard of care for TNBC since only one type of targeted therapy has been recently developed. References for metal-based compounds studied in TNBC cell lines will be listed, and those of metal-specific reviews, but a detailed overview will also be provided on compounds studied in vivo (mostly in mice models) and those compounds for which some preliminary mechanistic data was obtained (in TNBC cell lines and tumors) and/or for which bioactive ligands have been used. The main goal of this review is to highlight the most promising metal-based compounds with potential as chemotherapeutic agents in TNBC.
Conflict of interest
The authors declare no conflict of interest.
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