Volume 27, Issue 21 p. 6355-6355
Cover Picture
Free Access

Cover Feature: Dipyrrinato-Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation (Chem. Eur. J. 21/2021)

Benjamin F. Hohlfeld

Benjamin F. Hohlfeld

Institut für Chemie u. Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany

biolitec research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany

Search for more papers by this author
Dr. Burkhard Gitter

Dr. Burkhard Gitter

biolitec research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany

Search for more papers by this author
Dr. Christopher J. Kingsbury

Dr. Christopher J. Kingsbury

Medicinal Chemistry, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Trinity College Dublin, The University of Dublin, St James's Hospital, Dublin, 8 Ireland

Search for more papers by this author
Dr. Keith J. Flanagan

Dr. Keith J. Flanagan

Medicinal Chemistry, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Trinity College Dublin, The University of Dublin, St James's Hospital, Dublin, 8 Ireland

Search for more papers by this author
Dorika Steen

Dorika Steen

biolitec research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany

Search for more papers by this author
Dr. Gerhard D. Wieland

Dr. Gerhard D. Wieland

biolitec research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany

Search for more papers by this author
Prof. Dr. Nora Kulak

Prof. Dr. Nora Kulak

Institut für Chemie u. Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany

Institut für Chemie, Otto-von-Guericke-Universität Magdeburg, Universitätsplatz 2, 39106 Magdeburg, Germany

Search for more papers by this author
Prof. Dr. Mathias O. Senge

Corresponding Author

Prof. Dr. Mathias O. Senge

Medicinal Chemistry, Trinity Translational Medicine Institute, Trinity Centre for Health Sciences, Trinity College Dublin, The University of Dublin, St James's Hospital, Dublin, 8 Ireland

Institute for Advanced Study (TUM-IAS), Technical University of Munich, Lichtenbergstrasse 2a, 85748 Garching, Germany

Search for more papers by this author
Dr. Arno Wiehe

Corresponding Author

Dr. Arno Wiehe

Institut für Chemie u. Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany

biolitec research GmbH, Otto-Schott-Str. 15, 07745 Jena, Germany

Search for more papers by this author
First published: 12 February 2021

Graphical Abstract

Coordination complexes of iridium(III) are potential candidates for photodynamic therapy. Phenylpyridyl- and Cp*-containing (dipyrrinato)iridium(III) complexes with a multitude of functional groups at the dipyrrin moieties were synthesized and the phototoxic activity of the complexes evaluated in tumor and bacterial cell assays. The Cp*-containing and glycosylated dipyrrinato-phenylpyridyl complexes are promising photoactive agents, as visualized in the cover design by Ella Marushchenko. More information can be found in the Full Paper by M. O. Senge, A. Wiehe, et al. on page 6440.