Coordination complexes of iridium(III) are potential candidates for photodynamic therapy. Phenylpyridyl- and Cp*-containing (dipyrrinato)iridium(III) complexes with a multitude of functional groups at the dipyrrin moieties were synthesized and the phototoxic activity of the complexes evaluated in tumor and bacterial cell assays. The Cp*-containing and glycosylated dipyrrinato-phenylpyridyl complexes are promising photoactive agents, as visualized in the cover design by Ella Marushchenko. More information can be found in the Full Paper by M. O. Senge, A. Wiehe, et al. on page 6440.