Volume 3, Issue 3 p. 413-417
Communication

On the use of PIPSA to Guide Target-Selective Drug Design

Stefan Henrich Dr.

Stefan Henrich Dr.

EML Research GmbH, Schloss-Wolfsbrunnenweg 33, 69118 Heidelberg, Germany, Fax: (+49) 6221-533-298

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Stefan Richter Dr.

Stefan Richter Dr.

EML Research GmbH, Schloss-Wolfsbrunnenweg 33, 69118 Heidelberg, Germany, Fax: (+49) 6221-533-298

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Rebecca C. Wade Dr.

Rebecca C. Wade Dr.

EML Research GmbH, Schloss-Wolfsbrunnenweg 33, 69118 Heidelberg, Germany, Fax: (+49) 6221-533-298

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First published: 07 March 2008
Citations: 12

Graphical Abstract

Predicting proteins. PIPSA (Protein Interaction Property Similarity Analysis) provides a means to detect similarities and differences in the interaction fields of structurally related proteins and can therefore assist in identification of regions of proteins to target for selective ligand design. Herein, this is illustrated by application of PIPSA to dihydrofolate reductase, an important drug target.