Volume 7, Issue 2 p. 218-222
Communication

Immunosuppressive Effects of Subglutinol Derivatives

Won-Gil Lee

Won-Gil Lee

School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro(Oryong- dong), Buk-gu, Gwangju 500-712 (Republic of Korea)

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Woo-Seok Kim

Woo-Seok Kim

School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro(Oryong- dong), Buk-gu, Gwangju 500-712 (Republic of Korea)

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Prof. Dr. Sung-Gyoo Park

Prof. Dr. Sung-Gyoo Park

School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro(Oryong- dong), Buk-gu, Gwangju 500-712 (Republic of Korea)

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Prof. Dr. Hyoungsu Kim

Prof. Dr. Hyoungsu Kim

College of Pharmacy, Ajou University, San 5, Woncheon-dong, Yeongtong-gu, Suwon, 443-749 (Republic of Korea)

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Prof. Dr. Jiyong Hong

Prof. Dr. Jiyong Hong

Department of Chemistry, Duke University, 124 Science Dr., Durham, NC 27708 (USA)

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Dr. Hyojin Ko

Dr. Hyojin Ko

Institute of Medical System Engineering, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro(Oryong- dong), Buk-gu, Gwangju 500-712 (Republic of Korea)

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Prof. Dr. Yong-Chul Kim

Corresponding Author

Prof. Dr. Yong-Chul Kim

School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro(Oryong- dong), Buk-gu, Gwangju 500-712 (Republic of Korea)

School of Life Sciences, Gwangju Institute of Science and Technology (GIST), 261 Cheomdan-gwagiro(Oryong- dong), Buk-gu, Gwangju 500-712 (Republic of Korea)Search for more papers by this author
First published: 24 November 2011
Citations: 9

Graphical Abstract

More than herbal remedies: Subglutinols A and B, natural diterpenoid pyrone immunosuppressive agents, and their synthetic intermediates were assayed to assess their functional mechanisms of immune modulation. Subglutinol A and its methyl-γ-pyrone derivative (10) significantly suppressed interleukin-2 production (IC50) by different T cells, and also efficiently inhibited the T cell expression of activation markers, CD25 and CD69. These preliminary results suggest the subglutinol structure as a lead for the design of novel immunosuppressive agents.