Volume 15, Issue 13 p. 2817-2822
Article

Macromolecule Loading into Spherical, Elliptical, Star-Like and Cubic Calcium Carbonate Carriers

Dr. Bogdan V. Parakhonskiy

Corresponding Author

Dr. Bogdan V. Parakhonskiy

BIOtech research center, Department of Physics, University of Trento via delle Regole 101, 38123 Mattarello (Italy), Fax: (+39) 0461 283659

Shubnikov Institute of Crystallography Russian Academy of Science, Leninskii prospekt 59, Moscow 119333 (Russia)

BIOtech research center, Department of Physics, University of Trento via delle Regole 101, 38123 Mattarello (Italy), Fax: (+39) 0461 283659===Search for more papers by this author
Dr. Alexey M. Yashchenok

Dr. Alexey M. Yashchenok

Department of Interfaces, Max-Planck Institute of Colloids and Interfaces, Golm/Potsdam, 14476 (Germany)

Search for more papers by this author
Dr. Senem Donatan

Dr. Senem Donatan

Department of Interfaces, Max-Planck Institute of Colloids and Interfaces, Golm/Potsdam, 14476 (Germany)

Search for more papers by this author
Dr. Dmitry V. Volodkin

Dr. Dmitry V. Volodkin

Dept Cellular Biotechnol & Biochips, AG Biofunct Coatings, Fraunhofer Institute for Biomedical Engineering, 14476 Potsdam (Germany)

Search for more papers by this author
Dr. Francesco Tessarolo

Dr. Francesco Tessarolo

Healthcare Research and Innovation Program (IRCS), Bruno Kessler Foundation, via Sommarive 18, 38123, Povo, Trento (Italy)

Search for more papers by this author
Prof. Renzo Antolini

Prof. Renzo Antolini

BIOtech research center, Department of Physics, University of Trento via delle Regole 101, 38123 Mattarello (Italy), Fax: (+39) 0461 283659

Search for more papers by this author
Prof. Helmuth Möhwald

Prof. Helmuth Möhwald

Department of Interfaces, Max-Planck Institute of Colloids and Interfaces, Golm/Potsdam, 14476 (Germany)

Search for more papers by this author
Prof. Andre G. Skirtach

Prof. Andre G. Skirtach

Department of Interfaces, Max-Planck Institute of Colloids and Interfaces, Golm/Potsdam, 14476 (Germany)

Department of Molecular Biotechnology & Center of NB-(NanoBio)-Photonics, 653 Coupure Links, 9000 Ghent (Belgium)

Search for more papers by this author
First published: 10 July 2014
Citations: 74

Graphical Abstract

Taking Shape: The synthesis of spherical, elliptical, starlike, and cubic calcium carbonate particles is presented. Variation of the reaction parameters influences not only the particles shape but also their size and porosity. As a result, the surface area and loading capacity of the particles can be controlled.

Abstract

We fabricated calcium carbonate particles with spherical, elliptical, star-like and cubical morphologies by varying relative salt concentrations and adding ethylene glycol as a solvent to slow down the rate of particle formation. The loading capacity of particles of different isotropic (spherical and cubical) and anisotropic (elliptical and star-like) geometries is investigated, and the surface area of such carriers is analysed. Potential applications of such drug delivery carriers are highlighted.