Volume 19, Issue 17 p. 2143-2147
Communication

Hyperpolarized Porous Silicon Nanoparticles: Potential Theragnostic Material for 29Si Magnetic Resonance Imaging

Hyeonglim Seo

Hyeonglim Seo

Department of Bionano Technology, Hanyang University, Ansan, 15588 South Korea

These authors contributed equally to this work.

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Ikjang Choi

Ikjang Choi

Department of Bionano Technology, Hanyang University, Ansan, 15588 South Korea

These authors contributed equally to this work.

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Prof.Dr. Nicholas Whiting

Prof.Dr. Nicholas Whiting

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA

Current address: Department of Physics & Astronomy, Department of Molecular & Cellular Biosciences, Rowan University, Glassboro, New Jersey, 08028 USA

These authors contributed equally to this work.

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Dr. Jingzhe Hu

Dr. Jingzhe Hu

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA

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Quy Son Luu

Quy Son Luu

Department of Bionano Technology, Hanyang University, Ansan, 15588 South Korea

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Dr. Shivanand Pudakalakatti

Dr. Shivanand Pudakalakatti

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA

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Caitlin McCowan

Caitlin McCowan

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA

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Yaewon Kim

Yaewon Kim

Department of Chemistry, Texas A&M University College Station, TX 77843 USA

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Prof. Dr. Niki Zacharias

Prof. Dr. Niki Zacharias

Department of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA

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Prof. Dr. Seunghyun Lee

Corresponding Author

Prof. Dr. Seunghyun Lee

Department of Nanochemistry, Gachon University, Seongnam, 13120 South Korea

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Prof. Dr. Pratip Bhattacharya

Corresponding Author

Prof. Dr. Pratip Bhattacharya

Department of Cancer Systems Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA

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Prof. Dr. Youngbok Lee

Corresponding Author

Prof. Dr. Youngbok Lee

Department of Bionano Technology, Hanyang University, Ansan, 15588 South Korea

Department of Chemical and Molecular Engineering, Hanyang University, Ansan, 15588 South Korea

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First published: 20 May 2018
Citations: 23

Graphical Abstract

Size-controlled porous silicon nanoparticles are synthesized and hyperpolarized via DNP technique to enhance their 29Si magnetic resonance signals. The particles exhibit long 29Si T1 times (∼25 mins) and could therefore have potential applications in medical imaging.

Abstract

Porous silicon nanoparticles have recently garnered attention as potentially-promising biomedical platforms for drug delivery and medical diagnostics. Here, we demonstrate porous silicon nanoparticles as contrast agents for 29Si magnetic resonance imaging. Size-controlled porous silicon nanoparticles were synthesized by magnesiothermic reduction of silica nanoparticles and were surface activated for further functionalization. Particles were hyperpolarized via dynamic nuclear polarization to enhance their 29Si MR signals; the particles demonstrated long 29Si spin-lattice relaxation (T1) times (∼25 mins), which suggests potential applicability for medical imaging. Furthermore, 29Si hyperpolarization levels were sufficient to allow 29Si MRI in phantoms. These results underscore the potential of porous silicon nanoparticles that, when combined with hyperpolarized magnetic resonance imaging, can be a powerful theragnostic deep tissue imaging platform to interrogate various biomolecular processes in vivo.