A Near-Infrared Fluorescence Chemosensor Based on Isothiocyanate-Aza-BODIPY for Cyanide Detection at the Parts per Billion Level: Applications in Buffer Media and Living Cell Imaging
Pornthip Piyanuch
Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000 Thailand
Search for more papers by this authorProf. Jitnapa Sirirak
Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000 Thailand
Search for more papers by this authorDr. Anyanee Kamkaew
School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000 Thailand
Search for more papers by this authorDr. Oratai Weeranantanapan
School of Preclinical Science, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000 Thailand
Search for more papers by this authorProf. Vinich Promarak
School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology Wangchan, Rayong, 21210 Thailand
Search for more papers by this authorProf. Kevin Burgess
Department of Chemistry, Texas A & M University College Station, TX 77842 USA
Search for more papers by this authorCorresponding Author
Prof. Nantanit Wanichacheva
Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000 Thailand
Search for more papers by this authorPornthip Piyanuch
Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000 Thailand
Search for more papers by this authorProf. Jitnapa Sirirak
Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000 Thailand
Search for more papers by this authorDr. Anyanee Kamkaew
School of Chemistry, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000 Thailand
Search for more papers by this authorDr. Oratai Weeranantanapan
School of Preclinical Science, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000 Thailand
Search for more papers by this authorProf. Vinich Promarak
School of Molecular Science and Engineering, Vidyasirimedhi Institute of Science and Technology Wangchan, Rayong, 21210 Thailand
Search for more papers by this authorProf. Kevin Burgess
Department of Chemistry, Texas A & M University College Station, TX 77842 USA
Search for more papers by this authorCorresponding Author
Prof. Nantanit Wanichacheva
Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom, 73000 Thailand
Search for more papers by this authorGraphical Abstract
Green light given: A novel near-infrared sensor contains an aza-BODIPY core with two isothiocyanate groups for CN− sensing and provides both near-infrared (NIR) fluorometric and colorimetric responses with a low detection limit of 19 ppb in buffer media. The sensor was also utilized as an intracellular CN− sensor with low cytotoxicity.
Abstract
A near-infrared chemodosimeter based on an aza-BODIPY dye was designed and synthesized. The sensor contains isothiocyanate groups for cyanide ion sensing. The sensing function was illustrated via the fluorescence changes in near-infrared frequencies as well as chromogenic changes which could be easily visualized with a detection limit of 19 ppb. The sensor provides high selectivity to CN− and discriminates other anions such as CH3COO−, HPO4−, HSO4−, ClO3−, CO32−, SO42−, NO3−, Cl−, F−, Br−, I−, and phenylalanine (Phe) in 50 % PBS buffer/acetonitrile at physiological pH. The potential of the sensor for CN− detection in both aqueous buffer solutions and living cells imaging was demonstrated.
Conflict of interest
The authors declare no conflict of interest.
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