Volume 2020, Issue 12 p. 1782-1782
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Free Access

Front Cover: Efficient Synthesis of Antigenic Trisaccharides Containing N-Acetylglucosamine: Protection of NHAc as NAc2 (Eur. J. Org. Chem. 12/2020)

Masato Tsutsui

Masato Tsutsui

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, 560-0043 Osaka, Japan

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Julinton Sianturi

Julinton Sianturi

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, 560-0043 Osaka, Japan

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Seiji Masui

Seiji Masui

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, 560-0043 Osaka, Japan

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Kento Tokunaga

Kento Tokunaga

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, 560-0043 Osaka, Japan

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Yoshiyuki Manabe

Corresponding Author

Yoshiyuki Manabe

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, 560-0043 Osaka, Japan

Core for Medicine and Science Collaborative Research and Education, Project Research Center for Fundamental Science, Osaka University, Osaka, Japan

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Koichi Fukase

Corresponding Author

Koichi Fukase

Department of Chemistry, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, 560-0043 Osaka, Japan

Core for Medicine and Science Collaborative Research and Education, Project Research Center for Fundamental Science, Osaka University, Osaka, Japan

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First published: 25 February 2020

Graphical Abstract

The Front Cover shows diacetyl strategy. This new synthetic strategy can contribute to efficient synthesis of glycans containing amino sugars. Acetamide (NHAc) is tentatively converted to diacetylimide (NAc2) during oligosaccharide construction. Because NAc2 protected fragments cannot form intermolecular hydrogen bonding, this strategy can improve the reactivity in glycosylation to realize the efficient construction of glycans. More information can be found in the Full Paper by Y. Manabe, K. Fukaseet al.

The Front Cover shows diacetyl strategy. This new synthetic strategy can contribute to efficient synthesis of glycans containing amino sugars. Acetamide (NHAc) is tentatively converted to diacetylimide (NAc2) during oligosaccharide construction. Because NAc2 protected fragments cannot form intermolecular hydrogen bonding, this strategy can improve the reactivity in glycosylation to realize the efficient construction of glycans. More information can be found in the Full Paper by Y. Manabe, K. Fukaseet al.