Volume 27, Issue 48 e202400995
Concept

Transition-Metal-Catalyzed Construction of Axially Chiral Carbonyl Compounds

Yu Yan

Yu Yan

College of Chemistry and Chemical Engineering, Inner Mongolia University, 235 West University Street, Hohhot, 010021 China

These authors contributed equally to this work

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Min Pan

Min Pan

Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, 610064 China

These authors contributed equally to this work

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Jialin Ming

Corresponding Author

Jialin Ming

College of Chemistry and Chemical Engineering, Inner Mongolia University, 235 West University Street, Hohhot, 010021 China

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Jun-Ping Yue

Jun-Ping Yue

Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, 610064 China

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Xiao-Wang Chen

Xiao-Wang Chen

Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, 610064 China

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Yong-Yuan Gui

Corresponding Author

Yong-Yuan Gui

College of Chemistry and Materials Science, Sichuan Normal University, 5 Jingan Road, Chengdu, 610068 China

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Da-Gang Yu

Corresponding Author

Da-Gang Yu

Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu, 610064 China

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Dedicated to Professor Xiaoming Feng and Professor Yong Tang on the occasion of their 60th birthdays.
First published: 31 October 2024
Citations: 1

Graphical Abstract

Axially chiral carbonyl compounds are widespread in biologically active compounds and are useful chiral ligands or organocatalysts in asymmetric catalysis. Transition-metal-catalyzed approaches have become powerful tools for constructing axially chiral carbonyl compounds, offering high efficiency, selectivity, and versatility. This concept aims to provide a comprehensive overview of recent advances in the asymmetric synthesis of axially chiral carbonyl compounds. According to the reaction mode, the discussion is mainly divided into four categories: cross-coupling reactions, cycloaddition reactions, desymmetrization reactions, and other C−H activation reactions.

Abstract

The synthesis of axially chiral carbonyl compounds has attracted considerable interest in organic synthesis due to their prevalence in natural products and pharmaceuticals, as well as their utility in material science and catalysis. Transition-metal-catalyzed approaches have become powerful tools for their construction, offering high efficiency, selectivity, and versatility among the various methods developed. This concept aims to provide a comprehensive overview of recent advances in the transition-metal-catalyzed asymmetric synthesis of axially chiral carbonyl compounds, integrating scattered work with different catalytic systems. This feature concept is divided into four types of reactions based on the strategies employed: cross-coupling reactions, cycloaddition reactions, desymmetrization reactions, and other C−H activation reactions.

Conflict of Interests

There are no conflicts to declare.

Data Availability Statement

Data sharing is not applicable to this article as no new data were created or analyzed in this study.