Volume 6, Issue 42 p. 11664-11674
Full Paper

Glucose-Induced Disintegrated Hydrogel for the Glucose-Responsive Delivery of Insulin

Yangyang Lu

Yangyang Lu

State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027 China

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Dr. Haojie Yu

Corresponding Author

Dr. Haojie Yu

State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027 China

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Prof. Li Wang

Prof. Li Wang

State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027 China

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Di Shen

Di Shen

State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027 China

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Jian Liu

Jian Liu

Department of Surgical Oncology, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, 310027 China

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First published: 09 November 2021
Citations: 7

Graphical Abstract

Dynamically crosslinked hydrogels were prepared via the combination of 4-carboxy-3-fluorophenylboronic grafted chitooligosaccharides (CSPBA) and guar gum (GG). The reversible phenylborate ester bonds between PBA on CSPBA and galactose/mannose residues on GG drove the formation of the hydrogel. The CSPBA/GG hydrogels had good injectability and self-healing ability due to the dynamically reversible crosslinking. What's more, the CSPBA/GG hydrogel exhibited glucose-induced disintegration and glucose concentration-dependent insulin release because of the glucose-sensitivity of phenylborate ester bonds.

Abstract

Stimulus-sensitive drug delivery materials are of vital significance to modern therapeutic technology. In particular, glucose-responsive hydrogels capable of biomimetic release of hypoglycemic drugs according to glucose concentrations are one of the current research hotspots. In this paper, an injectable, glucose-induced disintegrated natural-polysaccharide-based hydrogel with good self-healing ability and biocompatibility is reported. The glucose-responsiveness of the hydrogel stems from the reversible phenylborate ester bonds. The glucose-triggered disintegration and insulin release are demonstrated in the hydrogel in a physiological environment. The two polymers produced by the disintegration of the hydrogel have good biocompatibility and biodegradability. Therefore, the hydrogel is considered to result in the development of smart insulin delivery systems.

Conflict of interest

The authors declare no conflict of interest.