Synthesis of Cyclic Sulfite Diesters and their Evaluation as Sulfur Dioxide (SO2) Donors†
A previous version of this manuscript has been deposited on a preprint server (https://doi.org/10.26434/chemrxiv.9929618.v1)
Tunable release: 1,2-Cyclic sulfite diesters, a new class of reliable SO2 donors, dissociate in buffer to produce SO2 with tunable release profiles, through nucleophilic displacement. These SO2 donors enhance intracellular SO2 levels more efficiently than sodium bisulfite, the SO2 donor most commonly used for cellular studies.
Although sulfur dioxide (SO2) finds widespread use in the food industry as its hydrated sulfite form, a number of aspects of SO2 biology remain to be completely understood. Of the tools available for intracellular enhancement of SO2 levels, most suffer from poor cell permeability and a lack of control over SO2 release. We report 1,2-cyclic sulfite diesters as a new class of reliable SO2 donors that dissociate in buffer through nucleophilic displacement to produce SO2 with tunable release profiles. We provide data in support of the suitability of these SO2 donors to enhance intracellular SO2 levels more efficiently than sodium bisulfite, the most commonly used SO2 donor for cellular studies.
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