Volume 16, Issue 9 p. 1829-1837
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Mechanochemical Sensing: A Biomimetic Sensing Strategy

Prakash Shrestha,

Prakash Shrestha

Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242 (USA)

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Shankar Mandal,

Shankar Mandal

Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242 (USA)

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Prof. Hanbin Mao,

Corresponding Author

Prof. Hanbin Mao

Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242 (USA)

Department of Chemistry and Biochemistry, Kent State University, Kent, OH 44242 (USA)Search for more papers by this author
First published: 27 April 2015
Citations: 6

Abstract

One spanner short…︁ New mechanochemical biosensors that employ mechanochemical coupling strategies to overcome the issues of existing biosensors are reviewed. By monitoring changes in the mechanical properties of a single-molecule template upon analyte binding, single-molecule sensitivity can be reached.

Abstract

Existing biosensors employ two major components: analyte recognition and signal transduction. Although specificity is achieved through analyte recognition, sensitivity is usually enhanced through a chemical amplification stage that couples the two main units in a sensor. Although highly sensitive, the extra chemical amplification stage complicates the sensing protocol. In addition, it separates the two elements spatiotemporally, reducing the real-time response of the biosensor. In this review, we discuss the new mechanochemical biosensors that employ mechanochemical coupling strategies to overcome these issues. By monitoring changes in the mechanical properties of a single-molecule template upon analyte binding, single-molecule sensitivity is reached. As chemical amplification becomes unnecessary in this single-molecule mechanochemical sensing (SMMS) strategy, real-time sensing is achieved.