Syntheses and Applications of Malonamide Derivatives – A Minireview

Graphical Abstract

Malonamide derivatives have been known for over a century and found important applications across a broad range of chemical disciplines. Their synthesis from a range of starting materials has provided varied routes to access this sought-after class of compounds. This review looks to provide a critical analysis and most important advances to this field of synthetic chemistry, and as such, provide a toolbox of reactions for future researchers in this field.

Abstract

Malonamide derivatives are an important class of organic compounds utilized in an array of applications. As such, numerous research efforts have focused on ways to synthesize and decorate these molecules. This minireview is separated into sections focusing on syntheses of malonamide derivatives from key starting materials. Throughout this report, critical analysis of the routes to and applications of malonamide derivatives are documented, highlighting the adaptability across scientific fields.