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The European Journal of Organic Chemistry publishes contributions of original research and topical reviews on synthetic organic, bioorganic and physical organic chemistry, as well as catalysis and organic materials. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. Find out more.

EurJOC receives great support from its international Editorial and Advisory Boards. Learn more about our Board Members and their research in our special collection.

 

A Message to Our Readers, Authors, and Reviewers

We recognize that the COVID-19 pandemic is affecting everyone’s daily lives and the global research community in unprecedented ways. Although some research activities are slowly resuming, many institutions remain closed, with researchers working from home under unusual circumstances. Our editorial teams also continue to work remotely.

Throughout these challenging times, we aim to support our scientific community in any way possible. Given the possible disruption of experimental work, we kindly ask our reviewers to bear in mind that some experiments may be hard to do these days. Now more than ever, it is important to mention clearly which suggestions you consider to be essential. We are aware that authors and reviewers are doing their best to revise and review manuscripts given these circumstances and should you need extra time, please contact the corresponding editorial office without hesitation.

Please accept the best wishes of our editorial teams for your ongoing health and wellbeing.

EurJOC Virtual Symposium

The EurJOC editorial team together with Board Chair Burkhard König (University of Regensburg) are proud to host the EurJOC Virtual Symposium series! Watch our 3rd edition with three presentations by Varinder Aggarwal (University of Bristol), Tatiana Besset (INSA de Rouen, Université de Rouen), and Josep Cornellà (MPI für Kohlenforschung)!

 

On the Cover

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Front Cover: Highly Enantioselective Ring-Opening of meso-Epoxides with O- and N-Nucleophiles Catalyzed by a Chiral Sc(III)/bipyridine Complex (Eur. J. Org. Chem. 8/2021)
The Front Cover shows the Karlštejn Castle, a large Gothic castle founded in 1348 by Charles IV, Holy Roman Emperor-elect and King of Bohemia (and founder of University in Prague). The castle served as a place for safekeeping the Imperial as well as the Bohemian crown jewels, holy relics, and other royal treasures. From a synthetic chemist's point of view, chiral ligands enabling high asymmetric inductions can be also considered as jewels or treasures. Such a ligand is also Bolm's ligand analog (shown above the castle) that was used in combination with Sc(OTf)3 for highly enantioselective ring-opening of epoxides. More information can be found in the Full Paper by M. Kotora et al.
Cover Feature: Use of Perylene Diimides in Synthetic Photochemistry (Eur. J. Org. Chem. 8/2021)
The Cover Feature shows a classic C−C bond forming reaction driven by the photochemical activity of the most used perylene diimide (PDI). Indeed, this PDI is largely employed as organic photoredox catalyst for synthetic purposes. Thanks to its outstanding optical and redox properties, the PDIs have emerged as prominent chromophores capable of driving numerous relevant photocatalytic organic transformations. This Minireview highlights the recent advances within this field, with a specific focus on the various mechanistic pathways of the photo-reduction reaction of aryl halides, recently proposed in independent studies. More information can be found Minireview by M. Prato et al.
Front Cover: C(sp2)−Si Bond Functionalization through Intramolecular Activation by Alkoxides (Eur. J. Org. Chem. 7/2021)
The Front Cover shows the two possible tracks that trains can follow at a fork. This rail metaphor illustrates how an intermediate can evolve along two distinct pathways in C(sp2)-Si bond functionalizations via intramolecular activation by alkoxides. Such processes involve the formation of a common cyclic hypervalent silicon intermediate that allows the carbon-to-oxygen migration of the organosilyl group and thus the formation of a carbanionic species. The C(sp2)-Si bond cleavage can be either “endocyclic” (Brook rearrangement, right tracks) or “exocyclic”(left tracks). Cover design by Kajetan Bijouard. More information can be found in the Minireview by J. Oble, A. Perez-Luna et al.
Cover Feature: An Insight into Non-Covalent Interactions on the Bicyclo[1.1.1]pentane Scaffold (Eur. J. Org. Chem. 7/2021)
The Cover Feature shows artist Ella Marushenko′s view of the docking between an iodinated bicyclo(1.1.1)pentane (BCP) derivative and 1,4-diazabicyclo[2.2.2]octane (DABCO). It illustrates noncovalent interactions of the BCP scaffold and how they can be used for the precise assembly of molecular components in chemical space. More information on BCP interactions - studied by crystallographic and theoretical methods - can be found in the Full Paper by Cristina Trujillo, Mathias O. Senge et al.
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Press Release

Pharmaceutical Production with Reduced Waste

Platform technology for producing cephalosporin antibiotics

Pharmaceutical Production with Reduced Waste - Platform technology for producing cephalosporin antibiotics

Antibiotics save countless human lives – modern medicine without them is unimaginable. The largest proportion by volume of industrially produced antibiotics today are cephalosporins, structural variants of the first antibiotic, penicillin. Unfortunately, their production generates a considerable amount of waste products, some of which are questionable. In the European Journal of Organic Chemistry, scientists have now demonstrated that a newly developed, more ecological synthetic route is suitable for the production of a wide variety of cephalosporin antibiotics.

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