• Issue
    Volume 5, Issue 7
    2114-2370
    February 21, 2020

Cover Pictures

Free Access

Cover Picture: (07/2020)

  • Pages: 2114
  • First Published: 17 February 2020
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Communications

Organic & Supramolecular Chemistry

Synthesis and Derivatization of 3-Aroyl Pyroglutamic Acids

  • Pages: 2115-2118
  • First Published: 17 February 2020
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A novel and practical synthetic strategy for the preparation of enantiomerically pure 3-substituted pyroglutamic acid derivatives is based on a fast 5-exo-tet cyclization of the chloroacetylated amino acids. Further oxidation of prepared products afforded highly valuable scaffolds with the quaternary stereogenic center with excellent diastereoselectivity.

Full Papers

Organic & Supramolecular Chemistry

Anisotropic Nonlinear Optical and Optical Limiting Studies of an Ethylenediamminium Picrate Crystal with Femtosecond Excitation

  • Pages: 2119-2129
  • First Published: 17 February 2020
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Crystal orientation dependent 2PA induced optical limiting action of EDAPA crystal was studied by Z-scan technique under femtosecond laser excitation. (1 1 1) orientation of EDAPA crystal possess wide dynamic range (optical limiting threshold = 24.36 μJ/cm2 and laser damage threshold = 9.1 GW/cm2). Thus EPAPA crystal can be used towards development of laser safety devices for ultrashort pulse lasers.

Synthesis of 1,2,3-Triazole Tethered 3-Hydroxy-2-oxindoles: Promising Corrosion Inhibitors for Steel in Acidic Medium and Their Anti-Microbial Evaluation

  • Pages: 2130-2134
  • First Published: 17 February 2020
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A novel series of 1,2,3-triazole tethered 3-hydroxy-2-oxindoles (4 a-j) were synthesized under ball-milling conditions. The synthesized compound 4 i exhibited as corrosion inhibitors for mild steel in 1 M HCl solution, with efficiency of >70%. Further, the evaluation of antibacterial and antifungal activities demonstrated that compound 4 g possessed a significant potential to behave as an antimicrobial agent.

Analytical Chemistry

Synthesis and Binding Affinity of Hydrophobic Tail Containing Naphthalene Derivatives with Different Type of Organized Media

  • Pages: 2135-2141
  • First Published: 17 February 2020
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The two new fluorescent naphthalene derivatives (NPBU and NPME) have been synthesized and structurally characterized by various spectroscopic techniques. A comparative photophysical (steady-state and time-resolved fluorescence) studies of both the fluorophores (NPBU and NPME) in aqueous and organized media. Steady-state and time-resolved fluorescence properties of long aliphatic tail containing naphthalene derivative (NPBU) was used to understand the micellization process of SDS, CTAB and Triton X-100 surfactants. Whereas, short hydrophobic tail containing naphthalene derivative NPME, was not sensitive toward the micellization process of surfactants. The study state and time-resolved fluorescence of the NPBU showed formation of inclusion complex with β-CD. Whereas the short tail containing NPME could not showed and binding affinity with β-CD.

Catalysis

Preparation of Spry-Liked CdS-TiO2 One-Dimensional Composite Nanomaterial and Its Photocatalytic Degradation Efficiency

  • Pages: 2142-2147
  • First Published: 17 February 2020
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The spry-like one-dimensional CdS-TiO2 nanofibers with variable amount of CdS have been fabricated via electrospinning process followed by sulfidation treatment with hydrothermal method. The composite nanofibers are easy to reutilize and exhibit more enhanced photocatalytic activity than pure TiO2 nanofibers under the simulated sunlight irradiation, which possess the potential application to treat organic pollutants in waste water.

Ultra-Deep Oxidative Desulfurization of Model Oil Catalyzed by In Situ Carbon-Supported Vanadium Oxides Using Cumene Hydroperoxide as Oxidant

  • Pages: 2148-2156
  • First Published: 17 February 2020
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V2O5@Carbon composites were synthesized with EDTA-2Na and NH4VO3 as precursor through mixture and calcination method. The vanadium existed on not only the surface of carbon, but also in the matrix.V2O5@Carbon showed high catalytic property with cumene hydroperoxide as oxidant for oxidative desulfurization of model fuel. The catalyst can be used 7 times without significant decrease in catalytic activity, and regenerated simply through washing with acetonitrile.

Materials Science inc. Nanomaterials & Polymers

Hierarchical Nanostructured Benzoic Naphthalene Tetracarboxylic Di-imide Organic Cathode for Lithium Ion Battery

  • Pages: 2157-2163
  • First Published: 17 February 2020
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The synthesis of hierarchical nanostructured naphthalene based diimide molecule has been demonstrated as an organic cathode for the Li-ion batteries. The electrochemical study of such small heterocyclic organic molecules shows significant specific capacity and rate capability for LIBs.

Inorganic Chemistry

Selective Recognition of Different Tartratogermanate Anions using 1,10-phenantroline Complexes of Fe(II), Co(II), Ni(II)

  • Pages: 2164-2167
  • First Published: 17 February 2020
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The present study describes synthesis, structure determination and features of selective recognition of different tartratogermanate anions using 1,10-phenantroline cations of Fe(II), Co(II), Ni(II) through the formation of cation-anionic complexes with the potential biological activity.

Materials Science inc. Nanomaterials & Polymers

Controlled Release of 5-Fluorouracil from Alginate Hydrogels by Cold HMDSO−Plasma Surface Engineering

  • Pages: 2168-2178
  • First Published: 17 February 2020
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Cold hexamethyldisiloxane (HMDSO) plasma modification of polyvinyl alcohol/ alginate hydrogels rendered a hydrophobic surface with reduced wettability, rough topography, lower water uptake capacity and compact morphology. A controlled release profile for 5-Fluorouracil (5FU) to the colon was confirmed from the HMDSO-plasma coated hydrogels. Preliminary drug release kinetics assay revealed the predominance of polymer chain relaxational process on the drug release mechanism from HMDSO plasma-treated hydrogels.

Analytical Chemistry

Enzymatic Digestion Coupled to Surfactant-Assisted Dispersive Liquid-Liquid Microextraction: A Mild Approach for Determining Polybrominated Diphenyl Ethers in Human Hair Sample

  • Pages: 2179-2184
  • First Published: 17 February 2020
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Proteinase K was used to digest the hair and to release the polybrominated diphenyl ethers (PBDEs) from the matrix. The sodium dodecyl sulfate was simultaneously used as hair denaturing in the enzymatic digestion technique and dispersive agent in the surfactant assisted-dispersive liquid-liquid microextraction technique. The PBDEs were determined for the first time in human hair samples from Argentina within the range of 0.01-0.07 ng g−1.

Inorganic Chemistry

Two 3D Copper(II/I) Coordination Polymers: Structures, Energetic and Magnetic Properties

  • Pages: 2185-2189
  • First Published: 17 February 2020
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Two 3D copper(II/I) compounds have been synthesized by in situ hydro/solvothermal reaction. CuII compound shows a 3D structure with ((82⋅10) metal topology and exhibits antiferromagnetic coupling and CuI compound shows (83) metal topology and a high thermal stability.

Catalysis

Cobalt-Based MOF-Derived CoP/Hierarchical Porous Carbon (HPC) Composites as Robust Catalyst for Efficient Dehydrogenation of Ammonia-Borane

  • Pages: 2190-2196
  • First Published: 21 February 2020
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The hierarchically porous carbon supported non-precious CoP NPs by using Co–MOF-74 as self-sacrificed templates have been synthesized through a stepwise calcinations and phosphorization method. The resulted CoP@HPC−T composites toward the hydrolytic dehydrogenation of AB showed the remarkable catalytic performance.

Communications

Biological Chemistry & Chemical Biology

Synthesis of Mefenamic Acid Containing N-Glycoconjugates and Their Evaluation as Human COX-2 Enzyme Inhibitor

  • Pages: 2197-2200
  • First Published: 17 February 2020
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Eight new N-glycoconjugates containing amino acids with hydrophobic side chain and mefenamic acid have been synthesized and their COX-2 inhibition potential has been explored. Both, in vitro and in silico studies on inhibition are found to be complementary, where best result was obtained for tryptophan derivative. Acute toxicity (LD50) in rat has also been evaluated using GUSAR software, where acute oral toxicity for most of the glycoconjugates was found to be less than the pure mefenamic acid.

Full Papers

Catalysis

Triflic Acid Functionalized Carbon@Silica Composite: Synthesis and Applications in Organic Synthesis; DFT Studies of Indeno[1,2-b]indole

  • Pages: 2201-2213
  • First Published: 17 February 2020
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Novel solid acid catalyst, triflic acid functionalized carbon@silica composite (CStar@SiO2-TfOH) for the three component synthesis of hexahydroacridine-1,8-diones and indeno[1,2-b]indole-9,10-diones in water under mild reaction conditions was developed. DFT study has been performed to confirm the structureof 4b,9b-dihydroxy-5-(4-chlorophenyl)-7,7-dimethyl-4b,5,7,8-tetrahydroindeno[1,2-b]indole-9,10(6H,9bH)-dione, where experimental results correlate well with the theoretical data.

Communications

Biological Chemistry & Chemical Biology

Wortmannolol Induces Breast Cancer Cell Death In Vitro and In Vivo by Targeting Phosphoinositide 3-Kinase α

  • Pages: 2214-2218
  • First Published: 17 February 2020
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In silico screening of an in-house natural products database by targeting PI3Kα and confirmatory bioassays led to the identification of wortmannolol (1) as a novel inhibitor of PI3Kα. Compound 1 inhibited PI3Kα in a time- and concentration-dependent manner. Inhibition of the PI3 K/AKT signaling pathway by 1 led to apoptosis of MCF-7 cells and activation of the pro-apoptotic signals. Furthermore, 1 displayed potent anti-tumor activity in MCF-7 xenograft CB-17/SCID mice.

Organic & Supramolecular Chemistry

Synergistic Effect between Ultrasound Irradiation and Na2CO3 in N-Acylation Reaction: Applied for the Synthesis of Novel N-Acylcyanamide Derivatives

  • Pages: 2219-2224
  • First Published: 17 February 2020
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We comparatively investigate the base-promoted N-acylation of cyanamides under two different conditions, including ultrasound irradiation and conventional techniques. Concisely, we demonstrate the synergistic effect between Na2CO3 and ultrasonic irradiation, which results in high reaction yields and short reaction duration for the synthesis of N-acylcyanamides via efficient co-promoting procedure. Under this ultrasonic-assisted N-acylation strategy, the product yields and reaction duration are improved.

Full Papers

Catalysis

Magnetic Hollow Biocomposites Prepared from Lycopodium clavatum Pollens as Efficient Recyclable Catalyst

  • Pages: 2225-2231
  • First Published: 17 February 2020
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A new type magnetic hollow biocomposites (MgBC) from Lycopodium clavatum (LC) pollens was synthesized by using microwave chemistry and investigated their catalytic activities on the model reduction reaction of Rhodamine B (RhB). The produced MgBCs exhibited high efficiency and excellent catalytic reduction performance of RhB (100 % removed within 230 sec), which could be ascribed to high surface areas of the Fe3O4 in biological matrix.

Energy Technology & Environmental Science

Research on the Selectivity and Activity of Ethane Oxidation Dehydrogenation with CO2 on Cr-based Catalyst

  • Pages: 2232-2239
  • First Published: 17 February 2020
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Excessive load (>10 %) leads the aggregation of active phase and the increasing of grain size, which goes against catalytic activity. Furthermore, excessive load increases the crystallization of α-Cr2O3. The high activity of Cr based catalysts relay on the redox cycle of Cr3+/Cr6+. Amorphous Cr3+ can be oxidized by CO2 while crystalline Cr3+ hinders the process. Thus catalytic activity decreases.

Communications

Materials Science inc. Nanomaterials & Polymers

A Biomimetic-Mineralization-Inspired Hybrid Mesocrystal with Boosted Lithium Storage Properties

  • Pages: 2240-2246
  • First Published: 17 February 2020
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A biomimetic-mineralization-inspired strategy was demonstrated to construct mesostructured Fe3O4@CN hybrid anode material for lithium ion batteries. The hybridization of CN and Fe3O4 two electrochemically favorable components in such a hybrid mesostructure gains both structural and compositional benefits by effectively alleviating the volume change and improving electronic conductivity, leading to remarkable lithium storage properties.

Full Papers

Energy Technology & Environmental Science

Graphene Supported Boron Nitride Nanosheets as Advanced Electroanalytical Performance for Rechargeable Magnesium Storage System

  • Pages: 2247-2254
  • First Published: 17 February 2020
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In this study, graphene-boron nitride composites were prepared by using vacuum filtration method. The prepared G/BN-20% composite has round leaf-like morphology and edge thickness of 100 nm. G/BN-20% composite exhibits a discharge capacity of 105 mAhg−1 within 100 cycles when compared to the graphene and other composites. Great power of G/BN-20% can be attributed for synergetic effect of graphene and BN nanosheet.

Organic & Supramolecular Chemistry

Preparation, Characterization and Application of Cyclodextrin-Containing UV-Curable Waterborne Polyurethane Based on Guest Regulation

  • Pages: 2255-2262
  • First Published: 17 February 2020
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The UV-curable supramolecular waterborne polyurethane (PU) was successfully synthesized through the introduction of methylated-β-cyclodextrin (Me-β-CD). All test characterizations illustrate the mechanical and water resistance of PU fabric obtained by the host-guest inclusion was larger than that of the physical mixture.

Materials Science inc. Nanomaterials & Polymers

Size-Dependent Photoluminescence from Thiolate-Protected Water-Soluble Cobalt Nanoclusters

  • Pages: 2263-2270
  • First Published: 17 February 2020
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The PAGE separation of crude CoGS sample resulted in three bands of varying sizes which posses a size-dependent luminescence property. The smaller CoGS nanoclusters shows blue luminescence under 365 nm UV illuminator. The more restrictions in the non-radiative pathway motions for the smaller CoGS nanoclusters i. e., B1 causes the consequent increases in the radiative pathway helps to improve their photoluminescence(PL) efficiency. The enhanced quantum yield might be due to size-dependent ligand-metal-metal charge transfer(LMMCT) relaxations occurring at triplet- state Co clusters.

Catalysis

Organodiphosphonate Metal-Organic Frameworks Derived Ni-P@C Catalyst for Hydrogenation of Furfural

  • Pages: 2271-2278
  • First Published: 17 February 2020
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Ni−P-MOFs material was prepared using tetraethyl p-xylenediphosphate as the organic ligand. Ni−P@C catalyst with graphitized carbon-covering Ni2P particles was prepared by pyrolysis and in-situ reduction method using Ni−P−MOFs material as the precursor. Ni−P@C catalyst presented a high activity in furfural hydrogenation, and the selectivity of reaction products greatly dependent on the reaction temperature and reaction time.

Organic & Supramolecular Chemistry

Phenothiazine-Tethered 2-Aminopyridine-3-carbonitrile: Fluorescent Turn-Off Chemosensor for Fe3+ Ions and Picric Acid

  • Pages: 2279-2283
  • First Published: 17 February 2020
Description unavailable

2-Amino-4-(4-methoxyphenyl)-6-(10H-phenothiazin-2-yl)pyridine-3-carbonitrile exhibited orange fluorescence and detects Fe3+ and picric acid through fluorescence turn off mechanism with lower limit of detection of 4.9 μM and 98 nM, respectively. In addition the probe successfully quantifies Fe3+ and picric acid (PA) in spiked water samples.

Inorganic Chemistry

A “Turn-On” Fluorescence Probe for Selective Detection of Al3+ in Aqueous Environment: Crystal Structure, Theoretical and Cell Imaging Studies

  • Pages: 2284-2290
  • First Published: 17 February 2020
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(E)-N′-(2,4-dihydroxybenzylidene)furan-2-carbohydrazide (DBF) has been synthesized and characterized. DBF acts as highly selective fluorescent sensor for Al3+ over other cations. The binding constant (KB) and detection limit for Al3+ are determined. It has been utilized in intracellular detection of Al3+ ions.

Energy Technology & Environmental Science

Ameliorating Interfacial Issues of LiNi0.5Co0.2Mn0.3O2/Poly(propylene carbonate) by Introducing Graphene Interlayer for All-Solid-State Lithium Batteries

  • Pages: 2291-2299
  • First Published: 17 February 2020
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The interfacial reaction mechanism between LiNi0.5Co0.2Mn0.3O2 cathode and poly(propylene carbonate) solid polymer electrolyte was investigated. A composite cathode structure was designed by introducing a graphene interlayer on the cathode surface to suppress the side interfacial reaction and enhance the electrochemical performance.

Organic & Supramolecular Chemistry

Construction of a Novel Photoresponsive Supramolecular Fluorescent Hydrogel through Host-Guest Interaction between β-Cyclodextrin and Azobenzene

  • Pages: 2300-2305
  • First Published: 19 February 2020
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We report a novel photoresponsive supramolecular fluorescent hydrogel constructed via host-guest interaction between polymer 1 with pendant β-CD and tetraphenylethylene (TPE) in side chain and polymer 2 with pendant β-CD and TPE in side chain. The fluorescence intensity of hydrogel could be controlled by UV and visible light.

An Efficient Green Protocol for Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones Using SBA-16/GPTMS-TSC-CuI under Solvent-Free Conditions

  • Pages: 2306-2316
  • First Published: 19 February 2020
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A rapid, efficient, facile and environmentally benign synthesis of 2,3-dihydroquinazolin-4(1H)-ones aldehyde using SBA-16/GPTMS-TSC-CuI (as a mesostructured catalyst with unique “super-cage” structure) is reported.

Medicinal Chemistry & Drug Discovery

Isopropylpyrone and Phenylpyrones from the Leaves of Hypericum monogynum

  • Pages: 2317-2321
  • First Published: 19 February 2020
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A new isopropylpyrone, (±)-hypemonone F, and a new phenylpyrone, (±)-hypemonone G, along with five known phenylpyrone derivatives were isolated from the leaves of Hypericum monogynum. In addition, all isolated compounds were evaluated for their cytotoxic activities on tumor cells (HeLa and HepG2).

Materials Science inc. Nanomaterials & Polymers

Green Synthesis of Multifaceted Silver Nanoparticles Using the Flower Extract of Aerva lanata and Evaluation of Its Biological and Environmental Applications

  • Pages: 2322-2331
  • First Published: 19 February 2020
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The silver nanoparticles were successfully synthesized by using the flower extract of Aerva lanata. The synthesized silver nanoparticles were characterized by AFM, SEM and TEM. Further, silver nanoparticles exhibited intense antibacterial activity through damage the cell membrane and DNA. In cytotoxic study, the synthesized silver nanoparticles decreased the cell viability by formation of apoptotic bodies and DNA damage. In addition, the silver nanoparticles effectively degrade the methylene blue dye through photocatalysis process.

Catalysis

Cascade Reductive Rearrangement for the Stereoselective Synthesis of Multifunctional Piperidinones: A Combined Experimental and Computational Study

  • Pages: 2332-2336
  • First Published: 19 February 2020
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A unprecedented cascade ring-opening/reduction/annulation process of amino-substituted dihydropyrano[3,2-c]chromen-5(2H)-one framework has been realized for the stereoselective synthesis of the multifunctional piperidinones. Combined experimental and computational studies revealed the the plaussible mechanism. Scale-up synthesis, one-pot multi-step synthesis and biological studies proved the synthetic utility of this approach.

Analytical Chemistry

Investigation of Photostability of Istradefylline Aqueous Solution

  • Pages: 2337-2341
  • First Published: 19 February 2020
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It was found that Istradefylline aqueous solution were extremely unstable in light. Compared with the Istradefylline peak, the impurity peak increased from 39.6% at 5 minutes to 81.3% at 24 hours. It is proved that light has great influence on the stability of Istradefylline. The impurity was separated by preparative HPLC, and further characterized by MS and NMR as Z-Istradefylline, a photo degradation product of Istradefylline.

Energy Technology & Environmental Science

Preparation of Polyurea Microcapsules Containing Phase Change Materials Using Microfluidics

  • Pages: 2342-2347
  • First Published: 19 February 2020
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The schematic of the procedure of polyurea microcapsules containing phase change materials (MicroPCMs) is presented. The effects of the flow rate of continuous phase and dispersed phase, the emulsifier type, and the emulsifier dosage on MicroPCMs are investigated systemically. The highly monodisperse MicroPCMs show high encapsulation and energy storage efficiency.

Sustainable Chemistry

Synthesis and Properties of Waterborne Polyurethane Modified with Guar Gum Polysaccharide

  • Pages: 2348-2353
  • First Published: 19 February 2020
Description unavailable

Guar gum modified waterborne polyurethane (GWPU) was prepared by the prepolymerization method using isophorone diisocyanate (IPDI) and difunctional poly(ϵ-caprolactone) diol (PCL) as the hard and soft segment, guar gum (GG) as an internal crosslinking agent. The GG content had an obvious effect on the GWPU's performance. GWPU exhibited improvement in tensile strength, water resistance and thermal stability compared to the unmodified waterborne polyurethane.

Catalysis

Towards the Safe and Simple Production of Hydrocinnamic Acid by High-Performance Palladium on Charcoal Nanocatalyst and Modeling the Nanocatalyst Fabrication Method

  • Pages: 2354-2364
  • First Published: 19 February 2020
Description unavailable

The catalytic transfer hydrogenation of cinnamic acid over high-performance palladium supported on activated charcoal (Pd/AC) nanocatalyst as a safe and simple reaction is applied to prepare hydrocinnamic acid (HCA). Fabrication of the nanocatalyst and its optimization are done in this work to construct a new model. Activation enthalpy, entropy and Gibbs free energy are investigated in the mentioned reaction. This reaction over Pd/AC can provide HCA with high purity (99.1 %) and yield (98.6 %).

Medicinal Chemistry & Drug Discovery

Triosephosphate Isomerase Inhibitors as Potential Drugs against Clostridium perfringens

  • Pages: 2365-2370
  • First Published: 19 February 2020
Description unavailable

Development of new drugs against Clostridium perfringens, using the triosaphosphate isomerase glycolytic enzyme as a therapeutic target and using tools computational of interactions simulations (Docking), nine compounds were selected from a library of almost 500,000 compounds. The nine compounds were subsequently tested in in vitro assays with the recombinant enzyme, and two compounds (C2 and C4) were determined that decrease the enzymatic activity. With these results, the development of a new drug against this bacterium can be continued.